2. Composition
Each vial contains:

• Cephradine (as sterile cephradine monohydrate): 250 mg, 500 mg, or 1 g
• Excipients: Sodium hydroxide or hydrochloric acid may be used for pH adjustment.

3. Indications
Cephradine injection is indicated for the treatment of infections caused by susceptible organisms, including:

• Respiratory tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Urinary tract infections
• Septicemia
• Post-surgical infections

4. Dosage and Administration
Adults:

• Mild to moderate infections: 500 mg–1 g IM or IV every 6–12 hours
• Severe infections: Up to 2 g IV every 6–8 hours
• Maximum daily dose: 8 g/day

Children:

• 25–50 mg/kg/day IM or IV in divided doses every 6–12 hours
• Severe infections: Up to 100 mg/kg/day in divided doses

Method of Administration:

• IM: Reconstitute with sterile water for injection
• IV: Reconstitute and dilute with suitable IV fluids (e.g., normal saline, 5% dextrose)

5. Contraindications

• Known hypersensitivity to cephradine or other cephalosporins
• History of severe hypersensitivity (e.g., anaphylaxis) to penicillins

6. Warnings and Precautions

• Use with caution in patients with renal impairment – adjust dosage.
• Monitor for signs of allergic reactions or superinfection.
• Cross-sensitivity with penicillins may occur.
• Prolonged use may result in overgrowth of non-susceptible organisms (e.g., Candida).

7. Adverse Reactions
Common:

• Gastrointestinal: Nausea, vomiting, diarrhea
• Hypersensitivity: Rash, urticaria

Rare but serious:

• Anaphylaxis
• Stevens-Johnson syndrome
• Hemolytic anemia
• Neutropenia

8. Drug Interactions

• Nephrotoxic agents (e.g., aminoglycosides): Increased risk of renal toxicity
• Oral contraceptives: Cephalosporins may reduce efficacy
• Probenecid: Delays renal excretion, increases serum levels

9. Storage

• Store dry powder below 25°C.
• Reconstituted solution should be used immediately or within specified stability period (varies by formulation and diluent).
• Protect from light and moisture.

10. Mechanism of Action
Cephradine inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to lysis and death of susceptible bacteria.

11. Spectrum of Activity
Sensitive organisms:

• Staphylococcus aureus (non-MRSA)
• Streptococcus pneumoniae
• Escherichia coli
• Proteus mirabilis
• Klebsiella pneumoniae

Not active against:

• MRSA
• Pseudomonas aeruginosa
• Enterococci
• Anaerobes

12. Pregnancy and Lactation

• Pregnancy Category B: Animal studies show no fetal harm. Use only if clearly needed.
• Lactation: Small amounts excreted in breast milk; use with caution.