MERIONAL 75 IU (MENOTROPIN) – MEDICAL DESCRIPTION

Merional 75 IU is a hormonal fertility medication containing Menotropin (Human Menopausal Gonadotropin – hMG), a combination of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activities. It is used in fertility treatment to stimulate ovarian follicular development in women and support sperm production in selected men with hormonal deficiencies.

By providing gonadotropin activity, Merional helps regulate reproductive functions and supports medically supervised fertility treatments.

Indications & Uses

• Female Infertility: Stimulates ovarian follicular development in women with ovulatory disorders who require gonadotropin therapy.
• Assisted Reproductive Technology (ART): Supports controlled ovarian stimulation during IVF and other assisted reproduction procedures to promote the development of multiple follicles.
• Follicular Maturation: Promotes ovarian follicle growth and development as part of fertility treatment protocols.
• Male Infertility: May be used in selected men with hypogonadotropic hypogonadism, usually in combination with hCG, to stimulate spermatogenesis.

Active Ingredients

Each vial contains:

Note: The 75 IU menotropin provides 75 IU of FSH activity and 75 IU of LH activity; these are not separate 75 IU doses of menotropin.

Mechanism of Action

Merional works through the combined actions of FSH and LH:

• FSH: Stimulates the growth and development of ovarian follicles and supports estrogen production.
• LH: Supports ovarian steroid hormone production and contributes to follicular maturation and reproductive function.
• In men: Gonadotropin activity, together with appropriate hCG therapy, stimulates testicular function and supports sperm production in men with hypogonadotropic hypogonadism.

Dosage & Administration

• The dosage and treatment duration are individualized according to the patient's diagnosis, hormonal profile, and response to treatment.
• Administered by intramuscular or subcutaneous injection, according to the prescribed product instructions.
• The powder must be reconstituted using the supplied diluent before administration.
• Treatment requires specialist supervision and regular monitoring, including ultrasound assessment of ovarian response and hormonal measurements when indicated.

Important: The dose must never be adjusted without the treating fertility specialist's instructions.

Possible Side Effects

• Headache and dizziness.
• Abdominal discomfort, bloating, or pelvic pain.
• Nausea and vomiting.
• Injection-site pain, redness, or swelling.
• Breast tenderness.
• Ovarian enlargement.
• Ovarian hyperstimulation syndrome (OHSS).
• Multiple pregnancy.

Ovarian hyperstimulation syndrome (OHSS) can be serious. Severe abdominal pain, rapid abdominal swelling, persistent vomiting, sudden weight gain, or difficulty breathing require immediate medical assessment.

Contraindications & Precautions

Merional should not be used in patients with:

• Pregnancy.
• Primary ovarian failure or premature menopause.
• Unexplained vaginal or uterine bleeding.
• Ovarian, uterine, breast, or other hormone-sensitive tumors.
• Pituitary or hypothalamic tumors.
• Uncontrolled thyroid or adrenal disorders.
• Ovarian cysts or enlargement unrelated to polycystic ovary syndrome.

Precautions:

• Requires careful monitoring to minimize OHSS and multiple pregnancy risks.
• Use cautiously in patients with a history or risk factors for thromboembolic disorders.
• Should only be prescribed and monitored by a fertility specialist.

Storage Conditions

• Store according to the manufacturer's package insert.
• Protect the powder from excessive heat and light.
• Keep out of reach of children.
• After reconstitution, use according to the product instructions; do not retain unused solution unless specifically permitted by the manufacturer.

Packaging

• Strength: 75 IU Menotropin (75 IU FSH + 75 IU LH activity).
• Dosage form: Powder for solution for injection.
• Pack size: 1 vial of powder + 1 ampoule of diluent.
• Route: Intramuscular or subcutaneous injection, as directed by the product instructions and prescribing specialist.

References & Scientific Sources

The following trusted medical and professional sources support the description:

1. U.S. National Library of Medicine – DailyMed (.gov): Menotropins – Official Drug Information. Composition, pharmacology, warnings, and safety information.
2. American Society for Reproductive Medicine (.org): Use of Exogenous Gonadotropins for Ovulation Induction. Clinical applications and treatment considerations.
3. American Society for Reproductive Medicine – ReproductiveFacts (.org): Side Effects of Injectable Fertility Drugs. Mechanism, indications, and adverse effects.
4. Society for Assisted Reproductive Technology (.org): ART Medications. Gonadotropin use in assisted reproductive technology.
5. European Association of Urology (.org): Male Infertility Guidelines. Gonadotropin therapy in male hypogonadotropic hypogonadism.
6. Merional 75 IU Product Information: Merional 75 IU – Product Leaflet. Product-specific composition and approved indications.

Patient Disclaimer

This medication is a prescription-only hormonal fertility treatment and must be used strictly under the supervision of a qualified fertility specialist. Dosage, administration, and treatment duration must be individualized according to the patient's medical condition and response to therapy. It should not be used without appropriate medical evaluation and monitoring. This information is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.