MEGA STAR GTN Hemorrhoids Treatment Cream

Glyceryl Trinitrate (GTN) + Clove Extract + D-Panthenol — 50 mL

Therapeutic Category: Topical Anorectal Preparation | Nitrate Vasodilator | Symptomatic Hemorrhoid and Anal Fissure Care

Ingredients provided:

• Glyceryl trinitrate (GTN) — active vasodilator.
• Clove extract — botanical ingredient.
• D-panthenol — skin-conditioning and moisturizing ingredient.
• Stearic acid — cream base and consistency agent.
• Parabens — preservatives.

Dosage Form: Topical cream Pack Size: 50 mL

Medical Description

Mega Star GTN is marketed as a topical preparation for hemorrhoid-related discomfort and anorectal symptoms. Glyceryl trinitrate is a nitrate vasodilator that relaxes smooth muscle. In appropriate anorectal formulations, it reduces internal anal sphincter pressure and may improve local blood flow, helping relieve pain associated particularly with chronic anal fissures.

D-panthenol helps condition and moisturize the skin, while clove extract is included as a botanical ingredient. Stearic acid contributes to the cream's consistency, and parabens serve as preservatives.

Indications and Potential Benefits

Depending on the verified formulation and its approved labeling, topical GTN preparations may be used for:

• Anal fissures: Helps relax the internal anal sphincter and reduce fissure-associated pain.
• Anorectal discomfort: May help relieve pain associated with sphincter spasm when GTN is appropriately prescribed.
• Wound-care support: D-panthenol may help moisturize and condition the surrounding skin.
• Skin conditioning: The cream base helps spread the formulation over the intended application area.

Clinical note: Hemorrhoids and anal fissures are different conditions. GTN is an established treatment option for certain chronic anal fissures, but it is not a standard first-line treatment for hemorrhoids themselves.

Mechanism of Action

• Glyceryl trinitrate (GTN): Releases nitric oxide, which relaxes smooth muscle and reduces internal anal sphincter pressure. This may improve local blood flow and support healing of chronic anal fissures.
• Clove extract: A botanical ingredient traditionally used in topical preparations.
• D-panthenol: Acts as a humectant and skin-conditioning ingredient, supporting skin hydration.
• Stearic acid: Helps provide the cream's texture and consistency.
• Parabens: Help preserve the formulation against microbial contamination.

Directions for Use

• Follow the directions provided by the treating healthcare professional and the verified package leaflet.
• Do not apply internally or to damaged tissue unless the verified product instructions specifically permit this.
• Wash hands after application and avoid contact with the eyes.
• Do not increase the amount or frequency to obtain faster relief.

Possible Side Effects

GTN-containing topical preparations may cause:

• Headache, sometimes severe.
• Dizziness or light-headedness.
• Low blood pressure, particularly when standing.
• Flushing.
• Local irritation or burning.
• Occasionally, fainting due to a fall in blood pressure.

Important drug interactions: Do not combine GTN with erectile dysfunction medicines such as sildenafil, tadalafil, or vardenafil, or with riociguat, because dangerous hypotension may occur. Alcohol and other blood-pressure-lowering medicines may also increase dizziness or hypotension.

Seek urgent medical care for fainting, severe weakness, chest pain, or symptoms of a serious allergic reaction.

Warnings and Precautions

• Product authenticity: The Egyptian Drug Authority (EDA) issued alerts concerning suspicious or unidentified-source packaging of Mega Star GTN products. Its October 2025 notice specifically identified batch ZR489 of Mega Star Body Cream containing glyceryl trinitrate. A further 2026 EDA alert lists Mega Star GTN Cream and Mega Star Body Cream GTN under commercial-fraud notices. Verify the exact package, manufacturer, and batch with the EDA or a licensed pharmacist before use. Do not use a package that cannot be verified.
• Low blood pressure: Use particular caution in patients with hypotension or a history of fainting.
• Cardiovascular conditions: Obtain medical advice before use in patients with significant heart disease or a recent heart attack.
• Drug interactions: Never combine GTN with PDE5 inhibitors such as sildenafil or tadalafil.
• Pregnancy and breastfeeding: Consult a healthcare professional before use.
• Rectal bleeding: Do not assume bleeding is caused by hemorrhoids; unexplained or persistent bleeding requires medical assessment.
• Persistent symptoms: Seek medical advice if pain or bleeding worsens or fails to improve.

Storage

• Follow the storage conditions on the verified manufacturer's packaging.
• Keep the container tightly closed and avoid contamination.
• Protect it from excessive heat and direct sunlight.
• Keep out of the reach of children.
• Do not use expired, damaged, or unverified products.

References

1. Egyptian Drug Authority (EDA) — .gov.eg: Official alert concerning Mega Star Body Cream containing glyceryl trinitrate, batch ZR489. Read the EDA product alert.
2. Egyptian Drug Authority (EDA) — .gov.eg: Official 2026 commercial-fraud notices, including Mega Star GTN Cream and Mega Star Body Cream GTN. View EDA 2026 alerts.
3. American Society of Colon and Rectal Surgeons — .org: Clinical practice guideline on anal fissures and the evidence for topical nitrates. Read clinical practice guidelines.
4. PubMed / National Library of Medicine — .gov: Clinical evidence concerning topical glyceryl trinitrate for chronic anal fissures. Read the clinical study.

Patient Disclaimer

This description is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The safety and effectiveness of this particular product cannot be confirmed from the ingredient list alone. Because regulatory alerts have been issued concerning certain Mega Star GTN packages, verify the exact product and batch with the Egyptian Drug Authority or a licensed pharmacist before use. GTN can cause severe headaches and dangerous drops in blood pressure and has potentially serious drug interactions. Do not use an unverified product or self-treat persistent anorectal bleeding without medical assessment.