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Brand: EVA PHARMA
Product Code: 6223002450909
Availability: Out Of Stock
Price: 44EGP
Ex Tax: 44EGP

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COMPOSITION

Each F.C. tablet contains:

 

Sildenafil (as citrate 100 mg 
 

PROPERTIES

Virecta is a safe and effective oral treatment for erectiledysfunction (ED) in men. ED is the persistent inability to achieve or sustain an erection sufficient for satisfactory sexual performance, a satisfactory  treatment for this condition relies on the relaxation of the smooth muscles of the corpora carvernosa to facilitate erection. Sildenafil citrate is a selective inhibitor of type V phosphodiesterase (PDE5) that enhances the effect of nitric oxide (NO) which is released in the corpora in response to sexual stimulation. The release of NO stimulates the enzyme guanylate cyclase to produce cyclic GMP, which in turn relaxes arterial smooth muscle. Cyclic GMP is then broken down by PDE5. Sildenafil as a PDE5 inhibitor prevents the breakdown of cyclic GMP and hence prolongs arterial relaxation and inflow of arterial blood and thereby enhances erection. Virecta therefore causes erection only in the context of sexual stimulation.

 

INDICATIONS

For the treatment of erectile dysfunction.

 

CONTRA-INDICATION

In patients with known hypersensitivity to sildenafil or any of the components of the tablet.

In patients who are using organic nitrates, concomitant therapy with Virecta may potentiate the hypotensive effect of nitrates.

Not indicated for use in newborn, children or women.

In patients with pre-existing cardiovascular disease and those having atrophy of the optical nerve and decreased visual field.

Prolonged erection greater than 4 hours (painful erection greater than 6 hours in duration) the patient should seek immediate medical assistance .If priapism is not treated immediately; penile tissue damage and permanent loss of potency could result.

 

SIDE EFFECTS

With the prescribed dosage, the most common side effects, which are only mild to moderate and usually do not last longer than a few hours are:
headache, flushing of the face, dyspepsia, nasal congestion and to a lesser extent urinary tract infection, mild and transient color tinge to vision, sensitivity to light or blurred vision, diarrhea, dizziness and rash.

Other minor adverse effects that are less common and are not likely to occur are:
Vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, stomatitis, dry mouth, abnormal liver function tests, rectal hemorrhage, gingivitis.

Edema of the face, photosensitivity reaction, shock, asthenia, chills, abdominal pain, allergic reaction, chest pain.

Angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, postural hypertension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy. Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia and synovitis.

Anemia and leucopenia. Thirst, edema, gout, diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reactions, hypernatremia. Ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, decreased reflexes and hypesthesia. Asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, increased sputum and cough.

Urticaria, herpes simplex, pruritus, sweating, ulcer, contact & exfoliative dermatitis. Mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, deafness, ear pain, hemorrhage, cataract, dry eyes. Cystitis, nocturia, urinary frequency, breast enlargement, urinary incontinence, abnormal ejaculation, general edema and anorgasmia.

 

DOSAGE

Half to one tablet one hour before sexual activity. The maximum recommended dosing frequency is once per day.

A dose of 25mg(1/4 tablet) should be used in patients with hepatic impairment ,severe renal failure and age over 65 years old as a dose more than that may lead to increase in sildenafil serum level and so increase in both the efficacy and incidence of adverse effect.

Overdose: The medication is stopped and standard supportive measures are to be immediately adopted.

 

DRUG INTERACTIONS

It is not recommended to use Virecta in combination with other treatments for erectile dysfunction

Concomitant administration of the protease inhibitor ritonavir increases serum concentration of Sildenafil, also co-administration of the HIV protease inhibitor saquinavir increases the level of Sildenafil, caution should therefore be exercised in such patients

Co-administration of the potent cytochrome P450 3A4 inhibitors, Erythromycin, Ketoconazole and Itraconazole as well as the non specific CYP inhibitor Cimetidine increases the plasma level of Sildenafil through reduction of its clearance.

The CYP stimulant Rifampin decreases plasma level of Sildenafil.

 

PRECAUTION

Virecta should be used with caution and under medical supervision in patients associated with the following conditions:

Pre-existing cardiovascular disease such as angina, chest pain, heart failure, irregular heartbeats, hypotension or hypertension.

Severe hepatic or renal impairment.

Ages above 65 years.

Rare inherited disease of retinitis pigmentosa.

Blood diseases such as sickle cell anemia, multiple myeloma or leukemia, deformed penis, Peyronie's disease or an erection that lasted more than 4 hours.

Stomach ulcers or any type of bleeding problems.

 

STORAGE

Store below 30°C, in a dry place

Keep out of reach of children

 
 

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