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Brand: EIPICO
Product Code: 13845
Availability: In Stock
Price: 14EGP
Ex Tax: 14EGP

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FLUMOX 250 MG ( AMOXICILLIN + FLUCLOXACILLIN ) 12 CAPSULES

Composition

Each dosage unit contains Film coated Tablets Capsules 5 ml Suspension 
250 mg 500 mg
Amoxycillin
(as amoxycillin trihydrate)
500 mg
574 mg
125 mg
250 mg
286.9 mg
125 mg
143.47 mg
Flucloxacillin
(as flucloxacillin sodium momohydrate)
500 mg
544 mg
125 mg
250 mg
272.5 mg
125 mg
136.32 mg

Inactive ingredients: 

FLUMOX Film Coated Tablets:  Polyvinylpyrrolidone (Povidone K 30), crospovidone, microcrystalline cellulose PH 101, colloidal silicon dioxide (Aerosil 200), magnesium stearate.

FLUMOX Capsules: Maize starch, microcrystalline cellulose, talc purified, colloidal silicon dioxide, magnesium stearate.

FLUMOX Dry Mix: Colloidal silicon dioxide, carboxy methylcellulose sodium, lactose, propyl para-hydroxybenzoate, sodium citrate anhydrous, sucrose, cherry flavour oil, saccharin sodium, sodium cyclamate, asparatam, veltol plus, avicer RC 591.

Therapeutic Indications

FLUMOX is indicated in the treatment of a wide range of infections including: 

Respiratory tract infections: Bronchitis, pneumonia and empyema.

Ear, nose and throat infections: Otitis media, sinusitis, tonsillitis and pharyngitis.

Gastrointestinal tract infections: Enteritis, cholecystitis, typhoid and paratyphoid, mperitonitis and intra-abdominal abscesses, and biliary tract infections.

Genitourinary tract infections: Cystitis, pyelonephritis, prostatitis, gonorrhoea, and puerperal sepsis.

Skin and soft tissue infections: post- operative wound infections, boils, carbuncles, abscesses, cellulitis.

Bone infections: Osteomyelitis.

Other infections: Septicaemia and endocarditis.

Dosage and Administration

Adults: 

The Usual Oral Dose is FLUMOX 250, 500, or 1000 every 8 hours.

Children: 

Children up to 10 years of age: They may be given 125 to 250 mg every 8 hours.

Children under 40 kg: A dose of 20 to 40 mg/kg daily in divided doses every 8 hours, or 25 to 45 mg/kg daily in divided doses every 12 hours, may be used;

In infants less than 3 months old: The maximum dose should be 30 mg/kg daily in divided doses every 12 hours.

Reconstitution of FLUMOX Dry Mix: 

To make up first shake the bottle to loosen powder, then add the volume of water stated on carton box to the content of bottle and shake well. Once reconstituted, FLUMOX must be stored in a refrigerator and used within 10 days.

Contraindications

Known hypersensitivity to penicillin.

Warnings and Precautions

Doses should be reduced in severe renal impairment.

Drug Interactions

Concomitant administration of amoxycillin and anticoagulants from the coumarin class, may prolong the bleeding time. A dose adjustment of anticoagulants may be necessary.

Undesirable Effects


As with other penicillins, side-effects are usually infrequent, mild and transient including diarrhoea, indigestion and skin rashes.

 

Pharmacological Properties


FLUMOX is a combination of two semi-synthetic penicillins: amoxycillin (a broad-spectrum penicillin) and flucloxacillin (a penicillinase-resistant penicillin). This combination exhibits a bacterial activity against a wide range of Gram-positive and Gram-negative microorganisms.

FLUMOX exerts a bactericidal action on microorganisms including:

Penicillinase-producing and non-penicillinase-producing Staphylococci, Streptococcus pyogenes, pneumoniae, and faecalis; Corynebacterium diphtheriae, Clostridia spp., Bacillus anthracis; H. influenzae, Moraxella (Branhamella) catarrhalis, N. gonorrheae and meningitidis, E. coli, Proteus mirabilis, Salmonella, Bordetella pertussis, and Bacteroides melaninogenicus.

Pharmacokinetics: 

Both amoxycillin and flucloxacillin are acid-stable and are well-absorbed after oral administration. Amoxycillin is more rapidly absorbed than ampicillin producing higher plasma concentrations than those obtained with the same dose of ampicillin.

Peak plasma concentrations of amoxycillin and flucloxacillin are achieved after 1-2 hours. Amoxycillin and flucloxacillin are metabolized to a limited extent, and the unchanged drugs and metabolites are excreted in the urine by glomerular filtration and renal tubular secretion.

Storage

Store in a dry place at a temperature not exceeding 25°C, and protect from light.

Packaging

Flumox 1000 Film coated Tablets:  Box containing 3 (Al/PVC) strips of 5 film coated tablets each.

Flumox 250 mg Capsules:  Box containing 2 strips of 6 capsules each.

Flumox 500 mg Capsules:  Box containing 2 strips of 8 capsules each.

Flumox Dry Mix:  Box of 100 ml suspension after reconstitution.

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