Product Code: 91274
Availability: In Stock
Price: 13,000EGP
Ex Tax: 13,000EGP



You can return the product within 14 days of purchase.


You can return the product within 14 days of purchase.

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Harvoni (ledipasvir 90 mg  + sofosbuvir 400 mg  ) 28 coated tablets 

Ledipasvir/sofosbuvir (trade name Harvoni) is a two-drug combination for the treatment of hepatitis C. It is administered as a single daily pill containing 90 mg of the viral NS5A inhibitor ledipasvir and 400 mg of sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase.

Ledipasvir/sofosbuvir was developed by the pharmaceutical company Gilead Sciences and first marketed in October 2014. Taken daily for 8–12 weeks, it provides cure rates of 94% to 99% in people infected with genotype 1 (the most common form of hepatitis C in the U.S. and some European countries), irrespective of the presence or absence of liver cirrhosis or prior unsuccessful treatment. It has also been evaluated for the treatment of infection with other hepatitis C genotypes, and has shown promising results in genotypes 3 and 4

How should I take Harvoni?

Take Harvoni exactly as prescribed by your doctor. Harvoni is usually taken once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Harvoni with or without food. Take the medicine at the same time each day.

While using Harvoni, you may need frequent blood tests.

Store this medicine in the original container at room temperature away from moisture and heat

Harvoni side effects :

Get emergency medical help if you have signs of an allergic reaction to Harvoni: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

How does Harvoni work? : 

Hep C is a disease of the liver that is caused by a virus. A virus is a very tiny germ that makes copies of itself to survive by a process called replication. The Hep C virus has at least six different strains, which are also known as genotypes.

Harvoni is a direct-acting antiviral (DAA) medication. DAAs are a group of medications that directly block the ability of the hepatitis C virus to make copies of itself.

Harvoni is a combination of two DAAs. One is sofosbuvir, which is a nucleotide polymerase inhibitor, and the other is ledipasvir, which is an NS5A inhibitor. Sofosbuvir interferes with the reproduction of the virus’s genetic material, stopping the production of new Hep C virus. Ledipasvir works by interfering with a protein needed to complete the Hep C virus life cycle in the liver cell.

Hep C treatment can cure a person from Hep C. However, a person could get infected again.

Drug interactions : 

Always consult your doctor and pharmacist about all the other prescription and non-prescription drugs you are taking, including methadone or other opiate substitution therapies, herbs, supplements and street drugs.

Drug interactions occur when one medication affects how another is absorbed, used or flushed out of the body. Some drugs can interact with Harvoni, increasing or decreasing the level of one or both drugs in the body. Increased levels can lead to new or more severe side effects. Decreased levels may mean that the drug won’t be as effective.

 This is not a complete list of possible drug interactions with Harvoni.

It is not recommended to take Harvoni with the following medications:

  • medication to treat irregular heartbeat, such as amiodarone
  • cholesterol-lowering medication, such as rosuvastatin (Crestor)
  • anti-seizure medication, such as carbamazepine (Tegretol), phenobarbital, oxcarbazepine (Trileptal) and phenytoin (Dilantin)
  • some hepatitis C medications, such as simeprevir (Galexos)
  • tuberculosis medication, such as rifampin
  • any medicinal herbs, especially an herb used to treat depression – St. John’s wort (Hypericum perforatum), or hyperforin or hypericin, active ingredients in St. John’s wort
  • HIV medication, such as:
    • Stribild (elvitegravir + cobicistat + emtricitabine + tenofovir);
    • tipranavir (Aptivus) + ritonavir (Norvir)

When Harvoni is taken with the following medications it could potentially cause significant drug interactions:

  • antacids or buffered medications
  • HIV medication, such as:
    • Atripla (efavirenz + emtricitabine + tenofovir);
    • tenofovir (Viread and in Truvada) used together with atazanavir (Reyataz), darunavir (Prezista, Prezcobix) or Kaletra (lopinavir + ritonavir);
  • medication to treat indigestion, heartburn or ulcers, such as nizatidine (Axid), famotidine (Pepcid AC, Peptic Guard), ranitidine (Zantac), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Losec) and pantoprazole (Pantoloc)

Talk to your nurse, doctor and pharmacist if you are taking any of these medicines. One way to manage drug interactions is to make sure that your doctor and pharmacist know about everything you are taking, including prescription drugs, over-the-counter drugs, street drugs, herbal medications, supplements or anything else. If you have more than one doctor or pharmacist, it is possible for drug interactions to get missed. If more than one doctor is writing prescriptions for you, let each one know about everything you are taking. If possible, use the same pharmacy for all your prescriptions.


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