Product Code: 12017
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You can return the product within 14 days of purchase.

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Folic Acid 5 mg EIPICO ( Vitamin B 9 ) 20 tablets


Each tablet contains:

Folic Acid ........................................................................................... 5 mg

Inactive ingredients:

Microcrystalline cellulose, lactose, maize starch, talc powder, magnesium stearate.

Therapeutic Indications

Folic acid is a component of the B group of vitamins and is necessary for the normal production and maturation of red blood cells.

For the treatment of folate-deficient megaloblastic anaemia due to malnutrition, malabsorption syndromes (such as coeliac disease or sprue) and increased utilisation as in pregnancy. 

It should not be used alone in undiagnosed megaloblastic anaemia including in infancy, pernicious anaemia or macrocytic anaemia of unknown aetiology, unless administered with adequate amounts of hydroxocobalamin.

For the prophylaxis of drug-induced folate deficiency e.g. caused by administration of phenytoin, phenobarbital and primidone. 

For the prophylaxis against folate deficiency in chronic haemolytic states or in renal dialysis.

For the prevention of neural tube defects for woman planning a pregnancy and known to be at risk. 

Dosage and Administration

Adults (including the Elderly):

In Folate-deficient Megaloblastic Anaemia: 

5 mg daily for 4 months; up to 15 mg daily may be necessary for malabsorption states.

In Drug-induced Folate Deficiency: 

5 mg daily for 4 months; up to 15 mg daily may be necessary for malabsorption states.

For Prophylaxis in Chronic Haemolytic States or in Renal Dialysis: 

5 mg every 1-7 days depending on underlying disease.

Prevention of Neural Tube Defects in Women Known to be At Risk: 

5 mg daily started before conception and continued throughout the first trimester.


In Established Folate Deficiency: 5 mg daily continued to term.


For young children a more suitable dosage form should be used.

In Folate-deficient Megaloblastic Anaemia:

Children 1-18 years: 

5 mg daily for 4 months; maintenance 5 mg every 1-7 days.

In Haemolytic Anaemia; Metabolic Disorders:

Children 1-12 years: 

2.5 mg-5 mg once daily.

Children 12-18 years: 

5-10 mg once daily.

Prophylaxis of Folate Deficiency in Renal Dialysis:

Child 1-12 years: 

250 microgram/kg (max. 10 mg) once daily.

Children 12-18 years: 

5-10 mg once daily.


Long-term folate therapy is contraindicated in any patient with untreated cobalamin deficiency. This can be untreated pernicious anaemia or other cause of cobalamin deficiency, including lifelong vegetarians.                     

In elderly people, a cobalamin absorption test should be done before long-term folate therapy. Folate given to such patients for 3 months or longer, has precipitated cobalamin neuropathy. No harm results from short courses of folate.

Folic acid should never be given alone in the treatment of Addisonian pernicious anaemia and other vitamin B12 deficiency states, because it may precipitate the onset of subacute combined degeneration of the spinal cord.

Folic acid should not be used in malignant disease unless megaloblastic anaemia owing to folate deficiency is an important complication.

Known hypersensitiviy to the active ingredient or to any of the excipients.

Warnings and Precautions

Patients with vitamin B12 deficiency should not be treated with folic acid unless administered with adequate amounts of hydroxocobalamin, as it can mask the condition but the subacute irreversible damage to the nervous system will continue. The deficiency can be due to undiagnosed megaloblastic anaemia including in infancy, pernicious anaemia or macrocytic anaemia of unknown aetiology or other cause of cobalamin deficiency, including lifelong vegetarians.

Caution should be exercised when administering folic acid to patients who may have folate-dependent tumours.

This product is not intended for healthy pregnant women where lower doses are recommended, but for pregnant women with folic acid deficiency or women at risk for the reoccurrence of neural tube defects.

This product contains lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose – galactose malabsorption should not take this medicine.

Drug Interactions

Antiepileptics: If folic acid supplements are given to treat folate deficiency, which can be caused by the use of antiepileptics (phenytoin, phenobarbital and primidone), the serum antiepileptic levels may fall, leading to decreased seizure control in some patients.

Antibacterials: Chloramphenicol and co-trimoxazole may interfere with folate metabolism.

Sulfasalazine: Can reduce the absorption of folic acid.

Methotrexate: Folic acid may interfere with the toxic and therapeutic effects of methotrexate.

Pregnancy and Lactation


There are no known hazards to the use of folic acid in pregnancy, supplements of folic acid are often beneficial.

Non-drug-induced folic acid deficiency, or abnormal folate metabolism, is related to the occurrence of birth defects and some neural tube defects. Interference with folic acid metabolism or folate deficiency induced by drugs such as anticonvulsants and some antineoplastics early in pregnancy results in congenital anomalies. Lack of the vitamin or its metabolites may also be responsible for some cases of spontaneous abortion and intrauterine growth retardation.


Folic acid is actively excreted in human breast milk. Accumulation of folate in milk takes precedence over maternal folate needs. Levels of folic acid are relatively low in colostrum but as lactation proceeds, concentrations of the vitamin rise. No adverse effects have been observed in breastfed infants whose mothers were receiving folic acid.

Effects on ability to drive and to use machines

None known.

Undesirable Effects

Gastrointestinal disorders:

Rare (≥ 1/10,000 till < 1/1,000)

Anorexia, nausea, abdominal distension and flatulence.

Immune system disorders:

Rare (≥ 1/10,000 till < 1/1,000)

Allergic reactions, comprising erythema, rash, pruritus, urticaria, dyspnoea, and anaphylactic reactions (including shock).


No special procedures or antidote are likely to be needed.

Pharmacological Properties

Pharmacodynamic properties:

Folic acid is a member of the vitamin B group. It is used in the treatment and prevention of folate deficiency states.

Pharmacokinetic properties:


Folic acid is rapidly absorbed from the gastrointestinal tract, mainly from the proximal part of the small intestine. Dietary folates are stated to have about half the bioavailability of crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated and reduced by dihydrofolate reductase in the intestine to form 5-methyltetrahydrofolate (5MTHF).    Folic acid given therapeutically enters the portal circulation largely unchanged, since it is a poor substrate for reduction by dihydrofolate reductases.                                                                                     


Via portal circulation. 5MTHF from naturally occurring folate is extensively plasma bound. The principal storage site of folate is in the liver; it is also actively concentrated in the CSF. Folate is distributed into breast milk.     


Therapeutically given folic acid is converted into the metabolically active form 5MTHF in the plasma and liver. There is an enterohepatic circulation for folate.                                                                                        


Folate metabolites are eliminated in the urine and folate in excess of body requirements is excreted unchanged in the urine. Folic acid is removed by haemodialysis.


Store at a temperature not exceeding 30°C.


Folic Acid 5 mg Tablets: Box containing 2 strips of 10 tablets each. 

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