JAXOLIC — Medical Description

JAXOLIC (Methyl Folate 1000 mcg DFE + Vitamin B12 1000 mcg) — 30 Chewable Tablets

Product Overview

JAXOLIC is a vitamin supplement combining folate in the form of 5-methyltetrahydrofolate (5-MTHF), provided as its calcium salt, with vitamin B12 in the form of methylcobalamin. These essential B vitamins support normal red blood cell formation, DNA synthesis, neurological function, and homocysteine metabolism. The chewable tablet formulation provides a convenient way to supplement these nutrients when dietary intake is inadequate or supplementation is recommended by a healthcare professional.

Active Ingredients

DFE = Dietary Folate Equivalents. The declared 1000 mcg DFE is the folate amount expressed in DFE units; it should not automatically be interpreted as 1000 mcg of the calcium 5-MTHF compound itself.

Indications and Potential Benefits

JAXOLIC may be used as a nutritional supplement to:

• Support red blood cell formation: Folate and vitamin B12 are essential for normal blood cell production and help prevent megaloblastic anemia associated with deficiency of either nutrient.
• Support nervous system function: Vitamin B12 contributes to the normal functioning and maintenance of the nervous system.
• Support DNA synthesis and cell division: Folate and vitamin B12 participate in essential cellular processes required for growth and tissue maintenance.
• Support homocysteine metabolism: Both vitamins participate in biochemical pathways involved in converting homocysteine to methionine.
• Supplement folate and vitamin B12 intake: May be beneficial for individuals with inadequate dietary intake or an increased risk of deficiency, as assessed by a healthcare professional.

These benefits are primarily associated with maintaining adequate vitamin levels and correcting deficiencies; supplementation is not established to provide additional benefits in individuals who already have sufficient levels.

Mechanism of Action

Folate (5-MTHF): 5-Methyltetrahydrofolate is a biologically active form of folate involved in one-carbon metabolism, DNA synthesis, cell division, and the remethylation of homocysteine to methionine.

Vitamin B12 (methylcobalamin): Methylcobalamin is a metabolically active form of vitamin B12 that acts as a cofactor for methionine synthase. This enzyme supports the conversion of homocysteine to methionine and the regeneration of tetrahydrofolate, linking vitamin B12 and folate metabolism. Vitamin B12 also supports neurological function and normal red blood cell development.

Directions for Use

• Suggested use: Follow the manufacturer's instructions on the product label or the dosage recommended by a healthcare professional.
• Chew the tablet thoroughly before swallowing.
• Do not exceed the recommended daily intake unless directed by a healthcare professional.

The exact recommended dosage and minimum age should be confirmed from the manufacturer's label.

Warnings and Precautions

• Do not use if you are allergic to any of the product's ingredients.
• Consult a healthcare professional before use if you are pregnant, breastfeeding, have a medical condition, or are taking medication.
• Vitamin B12 deficiency may cause anemia and neurological complications. Appropriate evaluation is important if deficiency is suspected, particularly when symptoms such as persistent fatigue, numbness, tingling, or balance problems occur.
• Individuals taking metformin or long-term acid-suppressing medicines, such as proton pump inhibitors, should discuss vitamin B12 status and supplementation with their healthcare professional.
• Women who are planning pregnancy or could become pregnant should consult their healthcare professional about appropriate folic acid supplementation. 5-MTHF should not automatically be considered a substitute for the 400 mcg daily folic acid recommendation for neural tube defect prevention.

Possible Side Effects

Vitamin B12 is generally considered to have a low potential for toxicity. However, individual responses to supplements may vary.

Possible adverse effects may include:

• Gastrointestinal discomfort.
• Nausea or abdominal discomfort.
• Allergic reactions, rarely.

If an adverse reaction occurs, discontinue use and seek medical advice if symptoms persist or are severe.

Contraindications

• Known hypersensitivity to any ingredient in the formulation.
• Use in individuals with specific medical conditions or those taking interacting medicines should be assessed by a healthcare professional before supplementation.

Storage

• Store in a cool, dry place, away from direct sunlight and excessive heat.
• Keep the container tightly closed.
• Keep out of reach of children.
• Do not use after the expiry date or if the packaging seal is damaged.

References

1. National Institutes of Health, Office of Dietary Supplements — Folate: Health Professional Fact Sheet.
2. National Institutes of Health, Office of Dietary Supplements — Vitamin B12: Health Professional Fact Sheet.
3. Centers for Disease Control and Prevention — Folic Acid: Sources and Recommended Intake.
4. Centers for Disease Control and Prevention — Folic Acid: Facts for Clinicians.

Patient Disclaimer: JAXOLIC is a dietary supplement intended to help support nutritional needs. This information is provided for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. The supplement is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician or pharmacist before use, particularly if you are pregnant, breastfeeding, taking medication, or have an existing medical condition.