What is the most important thing I should know about LOKELMA?
LOKELMA can cause swelling (edema) caused by fluid retention in your body (such as hands, ankles, feet).

• LOKELMA contains 400 mg of sodium in each 5 g dose. Watch for signs of swelling in your body especially if you limit sodium in your diet or are likely to have fluid retention in your body due to heart or kidney problems. Your doctor may tell you to reduce the sodium in your diet
• If you are not on dialysis, your doctor may also tell you to increase the dose of your diuretic

If you are a hemodialysis patient:

• Do not take LOKELMA on dialysis days
• Tell your doctor if you suddenly feel sick such as decreased oral intake of food or fluids or diarrhea, as you may be at risk of developing low levels of potassium in your blood while on LOKELMA; therefore, your dose of LOKELMA may need to be adjusted

Tell your doctor(s) you are taking LOKELMA before having an abdominal X-ray as it may appear on the X-ray.

What should I tell my doctor before taking LOKELMA?
Before taking LOKELMA, tell your doctor about all your medical conditions, including

• problems having a bowel movement, including severe constipation, a blockage (obstruction) in your bowel, or dry hard stool that will not pass out of your rectum (impaction)
• problems with your bowels after surgery

What are the most common side effects with LOKELMA?
The most common side effect of LOKELMA is swelling in your body caused by fluid retention. Tell your doctor if you have any side effects that bother you or do not go away

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. LOKELMA may affect how some oral medicines work. Ask your doctor or pharmacist if you need to take LOKELMA 2 hours before or after other oral medicines

APPROVED USE
LOKELMA is a prescription medication for the treatment of high levels of potassium in the blood (hyperkalemia) in adults.

Please see the full Prescribing Information for LOKELMA.

You may report side effects related to AstraZeneca products.