Descriptions:

Apixaban is used to treat or prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. This medicine is used for several days after hip or knee replacement surgery while you are unable to walk. It is during this time that blood clots are most likely to form.

Apixaban is also used to prevent stroke and blood clots in patients with certain heart rhythm problem (eg, nonvalvular atrial fibrillation).

Apixaban is a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps preventing harmful clots from forming in the blood vessels.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

Tablet

Before Using:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric:
Appropriate studies have not been performed on the relationship of age to the effects of apixaban in the pediatric population. Safety and efficacy have not been established.

Geriatric:
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of apixaban in the elderly.

Breastfeeding:
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions:
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Defibrotide
Levoketoconazole
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir
Abciximab
Aceclofenac
Acemetacin
Acenocoumarol
Adagrasib
Alipogene Tiparvovec
Alteplase, Recombinant
Amiodarone
Amoxicillin
Amtolmetin Guacil
Anagrelide
Anistreplase
Apalutamide
Argatroban
Aspirin
Atazanavir
Bemiparin
Berotralstat
Betrixaban
Bivalirudin
Bromfenac
Bufexamac
Cangrelor
Caplacizumab-yhdp
Capmatinib
Carbamazepine
Celecoxib
Ceritinib
Choline Salicylate
Cilostazol
Citalopram
Clonixin
Clopidogrel
Cobicistat
Collagenase, Clostridium histolyticum
Conivaptan
Crizotinib
Cyclosporine
Dabigatran Etexilate
Dalteparin
Danaparoid
Darunavir
Desirudin
Desvenlafaxine
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Diltiazem
Dipyridamole
Dipyrone
Doxorubicin
Dronedarone
Drotrecogin Alfa
Droxicam
Duloxetine
Edoxaban
Enoxaparin
Enzalutamide
Epoprostenol
Eptifibatide
Erythromycin
Escitalopram
Etodolac
Etofenamate
Etoricoxib
Fedratinib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Fexinidazole
Floctafenine
Fluconazole
Flufenamic Acid
Fluoxetine
Flurbiprofen
Fluvoxamine
Fondaparinux
Fosphenytoin
Heparin
Ibrutinib
Ibuprofen
Iloprost
Imatinib
Indomethacin
Inotersen
Itraconazole
Ketoconazole
Ketoprofen
Ketorolac
Lenacapavir
Lepirudin
Levetiracetam
Levomilnacipran
Lornoxicam
Loxoprofen
Lumacaftor
Lumiracoxib
Mavacamten
Meclofenamate
Mefenamic Acid
Meloxicam
Melphalan
Methotrexate
Milnacipran
Morniflumate
Nabumetone
Nadroparin
Naproxen
Nefazodone
Nepafenac
Niflumic Acid
Nimesulide
Nimesulide Beta Cyclodextrin
Nintedanib
Omadacycline
Omaveloxolone
Orlistat
Oxaliplatin
Oxaprozin
Oxcarbazepine
Oxyphenbutazone
Parecoxib
Paroxetine
Pentosan Polysulfate Sodium
Phenindione
Phenobarbital
Phenprocoumon
Phenylbutazone
Phenytoin
Piketoprofen
Piracetam
Piroxicam
Posaconazole
Pranoprofen
Prasugrel
Primidone
Proglumetacin
Propyphenazone
Proquazone
Protein C
Reteplase, Recombinant
Rifampin
Ritonavir
Rivaroxaban
Rofecoxib
Sarecycline
Selexipag
Sertraline
Sibutramine
Simeprevir
St John's Wort
Streptokinase
Sulfinpyrazone
Sulindac
Sunitinib
Telaprevir
Tenecteplase
Tenoxicam
Testosterone
Tiaprofenic Acid
Ticagrelor
Ticlopidine
Tinzaparin
Tirofiban
Tolfenamic Acid
Tolmetin
Topiramate
Trazodone
Treprostinil
Tucatinib
Turmeric
Urokinase
Valdecoxib
Valproic Acid
Vandetanib
Venlafaxine
Verapamil
Vilazodone
Vinblastine
Vorapaxar
Voriconazole
Vortioxetine
Warfarin

Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Grapefruit Juice

Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Antiphospholipid syndrome or
Bleeding problems, history of or
Catheter insertion in the spine or
Liver disease, mild to moderate or
Surgery (eg, spine), recent or history of—Use with caution. The risk of bleeding may be increased.
Bleeding, active or
Liver disease, severe or
Prosthetic (artificial) heart valve—Should not be used in patients with these conditions.
Kidney disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.