MEDIHYALO CREAM

Silver Sulfadiazine 1% + Sodium Hyaluronate 0.2% — 30 g

Therapeutic Category: Topical Antimicrobial | Wound-Care Preparation | Skin-Healing Support

Active Ingredients:

• Silver sulfadiazine 1% — topical antimicrobial agent.
• Sodium hyaluronate 0.2% — a moisturizing agent that supports wound healing.

Dosage Form: Topical cream

Medical Description

Medihyalo Cream is a topical wound-care preparation combining silver sulfadiazine, an antimicrobial agent, with sodium hyaluronate, a form of hyaluronic acid that helps maintain a moist wound environment and supports tissue repair.

Silver sulfadiazine helps control susceptible microorganisms in burn wounds, while sodium hyaluronate contributes to hydration and supports the physiological wound-healing process. The combination is intended for local application to appropriate wounds, particularly burns, when indicated by a healthcare professional.

This combination may be useful when antimicrobial protection and wound-care support are both required. The precise approved indications should be confirmed using the product's local package leaflet.

Indications and Potential Benefits

Medihyalo may be used, as directed by a healthcare professional, for:

• Burn wound care: Helps prevent or control wound infection in suitable burn injuries.
• Antimicrobial protection: Silver sulfadiazine acts against a range of susceptible bacteria and some fungi.
• Wound hydration: Sodium hyaluronate helps maintain moisture at the wound surface.
• Support for tissue repair: A moist wound environment can support cell migration and the normal healing process.
• Selected skin lesions and wounds: May be considered when appropriate to the wound type and the product's approved indications.

Important: Silver sulfadiazine is an adjunct to appropriate burn care, not a substitute for burn assessment, wound cleansing, debridement when required, or other necessary medical treatment. Evidence for hyaluronic acid varies by wound type and formulation.

Mechanism of Action

Medihyalo combines two ingredients with complementary roles in wound care.

• Silver sulfadiazine 1%: Releases antimicrobial silver ions and provides sulfonamide-related antibacterial activity, helping inhibit susceptible microorganisms in burn wounds.
• Sodium hyaluronate 0.2%: Binds water and helps maintain a hydrated wound surface, supporting cell migration and tissue repair.

Together, these ingredients provide antimicrobial action and wound-healing support. However, the cream does not eliminate the need for appropriate wound assessment and infection management.

Directions for Use

• Clean the affected area gently according to the healthcare professional's instructions.
• Apply the cream topically in the amount and frequency recommended by the treating clinician or the product leaflet.
• Use clean hands or an appropriate sterile applicator when applying the product to a wound.
• Cover the treated area with a suitable sterile dressing if recommended.
• Reapply according to the prescribed wound-care schedule and instructions for dressing changes.
• Wash hands after application, unless the hands themselves are being treated.

Important: The amount and frequency depend on the type, size, and severity of the wound. Significant burns require medical assessment rather than self-treatment.

Possible Side Effects

Possible adverse effects include:

• Temporary burning, itching, or irritation at the application site.
• Skin rash or allergic reactions.
• Increased sensitivity to silver sulfadiazine or other sulfonamides.
• Rare blood-related adverse effects, including leukopenia.
• Rare but potentially serious skin reactions associated with sulfonamide medicines.

Seek medical advice if irritation persists, the wound becomes increasingly painful, redness spreads, discharge increases, or fever develops. Stop using the product and seek urgent care for signs of a severe allergic reaction or serious skin reaction.

Warnings and Precautions

• Sulfonamide allergy: Do not use if allergic to silver sulfadiazine or any ingredient in the cream. Tell your healthcare professional about previous reactions to sulfonamide medicines.
• Pregnancy: Silver sulfadiazine should not be used near full term because of the potential risk of bilirubin-related complications in the newborn.
• Infants: It is contraindicated in premature infants and newborns younger than 2 months under standard silver sulfadiazine labeling.
• Breastfeeding: Consult a healthcare professional before use, particularly if the infant is premature or younger than 2 months.
• Kidney or liver impairment: Seek medical advice before treating extensive wounds, because systemic absorption may increase with large areas of damaged skin.
• Large or deep burns: Require prompt medical evaluation and appropriate specialist wound care.
• Eye and mucosal contact: Avoid contact with the eyes and other areas unless specifically directed by the product instructions.
• Infection monitoring: Seek medical attention if the wound worsens or fails to improve.

Silver sulfadiazine can be absorbed through damaged skin, particularly when large areas are treated. Use under medical supervision when treating extensive burns or wounds.

Storage

• Store according to the manufacturer's instructions on the package.
• Keep the tube tightly closed when not in use.
• Avoid contamination of the tube opening and the cream.
• Keep out of the reach and sight of children.
• Do not use after the expiry date or if the product's appearance has changed unexpectedly.

References

1. DailyMed — U.S. National Library of Medicine (.gov): Official prescribing information for silver sulfadiazine 1% cream, including indications, contraindications, warnings, and adverse effects. Read prescribing information.
2. MedlinePlus — U.S. National Library of Medicine (.gov): Patient guidance on silver sulfadiazine use and precautions. Read patient drug information.
3. Cochrane (.org): Systematic review of hyaluronic acid-containing dressings and topical agents for chronic wound healing. Read the evidence review.
4. PubMed — National Library of Medicine (.gov): Randomized clinical trial evaluating 0.2% hyaluronic acid cream in chronic leg ulcers. Read the clinical study.
5. Medihyalo product listing: Product composition and 30 g presentation. View product information.

Patient Disclaimer

This description is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Medihyalo Cream should be used according to the manufacturer's instructions and appropriate healthcare guidance. Seek medical assessment for significant burns, deep wounds, signs of infection, or worsening symptoms. Consult a qualified healthcare professional before use in infants, during pregnancy or breastfeeding, or if you have a known sulfonamide allergy.