Mebeverine Hydrochloride – Medical Description

Mebeverine hydrochloride is an antispasmodic medication used to relieve gastrointestinal smooth muscle spasms. It acts directly on the muscles of the intestine, helping to reduce abdominal pain, cramping, bloating, and bowel discomfort without significantly affecting normal intestinal motility. Mebeverine is commonly prescribed for the symptomatic management of irritable bowel syndrome (IBS) and related functional gastrointestinal disorders.

Indications

Mebeverine may be indicated for the symptomatic relief of:

• Irritable bowel syndrome (IBS)
• Abdominal pain and cramping associated with intestinal spasm
• Bloating and flatulence
• Spastic constipation
• Functional bowel disorders
• Altered bowel habits associated with IBS, including diarrhea or constipation

Mechanism of Action

Mebeverine works by relaxing the smooth muscles of the gastrointestinal tract, thereby reducing intestinal spasms and relieving pain and discomfort. Unlike some antispasmodic agents, it generally does not produce significant anticholinergic side effects.

Dosage and Administration

Mebeverine 135 mg Tablets

• Adults: One tablet (135 mg) three times daily.
• Tablets are preferably taken 20 minutes before meals.

Modified-Release Capsules (200 mg)

• Adults: One capsule (200 mg) twice daily, preferably before breakfast and the evening meal.

Pediatric use: Mebeverine is generally not recommended for children under 18 years of age unless specifically prescribed by a healthcare professional.

Directions for Use

• Take mebeverine approximately 20 minutes before meals.
• Swallow tablets or capsules whole with water.
• Do not crush, chew, or open modified-release capsules.
• Continue treatment as directed by your healthcare provider. Symptoms often improve within days, although some patients may require longer treatment.

Precautions and Warnings

Use with caution in patients who:

• Have unexplained weight loss or rectal bleeding
• Experience difficulty swallowing
• Develop persistent or worsening symptoms
• Have severe constipation or signs of bowel obstruction
• Are pregnant or breastfeeding (consult a physician before use)

Do not use if you have a known hypersensitivity or allergy to mebeverine or any component of the formulation.

Seek medical advice if symptoms fail to improve after 2 weeks of treatment or worsen during therapy.

Possible Side Effects

Mebeverine is generally well tolerated, and side effects are uncommon. Reported adverse effects may include:

• Skin rash or itching
• Urticaria (hives)
• Facial swelling or allergic reactions
• Dizziness
• Headache
• Mild gastrointestinal discomfort

Discontinue use and seek immediate medical attention if signs of a severe allergic reaction occur, such as swelling of the face, lips, tongue, or difficulty breathing.

Storage

• Store below 25–30°C according to local labeling.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Patient Disclaimer

This medication should be used only under the guidance of a healthcare professional. Do not exceed the recommended dose. Consult your physician if symptoms persist, worsen, or if new symptoms develop. Mebeverine is intended for symptomatic relief and does not treat the underlying cause of gastrointestinal disorders.