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Bambedil 10 mg ( bambuterol ) 30 tablets
Brand: WESTERN PHARMA
Product Code: 12419
Availability: In Stock
Price: 47EGP
Ex Tax: 47EGP

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Bambedil 10 mg ( bambuterol ) 30 tablets 

Concise Prescribing Info
Indications/Uses
Persistent reversible airways obstruction.
Dosage/Direction for Use
Adult : PO 10-20 mg/day at bedtime.
Dosage Details
Oral
Persistent reversible airways obstruction
Adult: 10-20 mg once daily at bedtime.
Renal Impairment
CrCl (mL/min) Dosage
<50 Initial dose should be halved.
Hepatic Impairment
Severe: Not recommended.
Special Precautions
Patient w/ liver cirrhosis and other causes of severely impaired liver function; underlying severe heart disease (e.g. ischaemic heart disease, arrhythmia or severe heart failure); thyrotoxicosis, DM, hypertrophic cardiomyopathy, predisposition to angle closure glaucoma. Not intended for relief of acute bronchospasm or in patients w/ unstable resp disease. Moderate to severe renal impairment. Pregnancy and lactation.
Adverse Reactions
Behavioural disturbances (e.g. restlessness, agitation), tremor, headache, sleep disturbances, palpitations, muscle cramps, hypersensitivity reactions, hypokalaemia, hyperglycaemia, dizziness, hyperactivity, tachycardia, cardiac arrhythmias, myocardial ischaemia, paradoxical bronchospasm, nausea.
Overdosage
Symptoms: Headache, anxiety, tremor, nausea, tonic muscle cramps, palpitations, tachycardia and cardiac arrhythmias. Management: Consider gastric lavage and activated charcoal in severe cases. Determine acid-base balance, blood glucose and electrolytes. Monitor BP, heart rate and rhythm. For haemodynamically significant cardiac arrhythmias, the preferred antidote is a cardioselective β-blocker, but should be used w/ caution in patients w/ history of bronchospasm. Admin a vol expander when the β2-mediated reduction in peripheral vascular resistance significantly contributes to the fall in BP.
Drug Interactions
Prolonged muscle-relaxing effect of other sympathomimetics (e.g. suxamethonium). Increased risk of hypokalaemia by co-admin w/ corticosteroids, diuretics or xanthine derivatives. Partial or total inhibition of effects w/ non-selective β-blockers.
Action
Description: Bambuterol is a prodrug of terbutaline. It relaxes bronchial smooth muscle by selectively acting on β2-receptors.
Duration: At least 24 hr.
Pharmacokinetics:
Absorption: Absorbed from the GI tract (approx 20%). Bioavailability: Approx 10%. Time to peak plasma concentration: Approx 4-7 hr (terbutaline).
Distribution: Plasma protein binding: 40-50%.
Metabolism: Slowly metabolised in the liver to its active metabolite, terbutaline via hydrolysis and oxidation.
Excretion: Terminal half-life: 9-17 hr.
 
Storage
Store below 30°C.

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