Carnivita Forte ( L - Carnitine 1 gm + Zinc Gluconate 50 mg ) 30 film-coated tablets

WHAT IS CARNITINE (CARNIVITA FORTE)?
Levocarnitine is used to prevent and treat a lack of Carnitine (Carnivita forte). It is used to prevent and treat this condition in patients with kidney disease on dialysis. It is given to people whose body cannot properly use Carnitine (Carnivita forte) from their diet. Lack of Carnitine (Carnivita forte) can lead to liver, heart, and muscle problems. Your doctor may treat lack of Carnitine (Carnivita forte) by prescribing levocarnitine for you.

Carnitine (Carnivita forte) comes in two forms. Levocarnitine (L-Carnitine (Carnivita forte)) should not be confused with the D,L-Carnitine (Carnivita forte) form (labeled as “vitamin B T”'). Only the L-form of Carnitine (Carnivita forte) is used by the body to treat serious Carnitine (Carnivita forte) deficiency. The D,L-form does not help the body use fat and can actually interfere with and cause a lack of levocarnitine.

Certain levocarnitine products have been specifically approved by the U.S. Food and Drug Administration for medical use and are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, levocarnitine is used in certain patients with the following medical condition:

Carnitine (Carnivita forte) deficiency that results from treatment with valproic acid

CARNITINE (CARNIVITA FORTE) INDICATIONS

1) Used to improve immunity in children and adult

Increase phagocytosis of granulocytes, increase stimulation of the T – lympfocytes induced by phytohemagglutinin and membrane activation of NK Cells ( Natural killer cells ) So, it has +ve influence on certain parameters of the immune system.

2) L-Carnitine (Carnivita forte) has a significant increase effect in peripheral blood supply and capacity dilatation as a result, oxygen absorption rise especially during exercise.

2)Used in cases of B – thalassemia

L-Carnitine (Carnivita forte) stabilizes red blood cells and supplementation may decrease the need for blood transfusions.

3) Improve lung functions in chronic lung diseases

4) Used in fat loss management, chronic fatigue syndrome and athletic performance.

5) L- Carnitine (Carnivita forte) Supplementation In Athletes

6) Research shows that people who supplement with L-Carnitine (Carnivita forte) while engaging in an exercise regimen are less likely to experience muscle soreness.5 However, the belief that Carnitine (Carnivita forte)

How to use Carnitine (Carnivita forte) (tartrate)

CARNITINE (CARNIVITA FORTE) DESCRIPTION

Levocarnitine (L-Carnitine (Carnivita forte)) is a naturally occurring biochemical that is used to treat Carnitine (Carnivita forte) deficiency.

CARNITINE (CARNIVITA FORTE) INTERACTIONS
Cimetidine

Cimetidine may enhance the myelosuppressive effects of carmustine.

Digoxin, phenytoin

Digoxin and phenytoin serum levels may be reduced by carmustine.

Laboratory Test Interactions

None well documented.

CARNITINE (CARNIVITA FORTE) SIDE EFFECTS

L-Carnitine (Carnivita forte) MEPACO has no significant side effects.

Rarely oral L- Carnitine (Carnivita forte) in high doses causes nausea and diarrhea, especially at

the beginning of usage. In this condition it is advisable to continue the

treatment and symptoms will disappear gradually.

Transient nausea and vomiting have been observed. Less frequent adverse

reactions are body odor, nausea, and gastritis.

CARNITINE (CARNIVITA FORTE) CONTRAINDICATIONS
None known

WHAT IS ZINC GLUCONATE (CARNIVITA FORTE)?
Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues.

Zinc Gluconate (Carnivita forte) is used to treat and to prevent zinc deficiency.

Zinc Gluconate (Carnivita forte) may also be used for other purposes not listed in this medication guide.

Zinc is a naturally occurring mineral. Zinc is important for growth and for the development and health of body tissues.

Zinc Gluconate (Carnivita forte) is used to treat and to prevent zinc deficiency

Use: Labeled Indications
Common cold: To reduce the duration and severity of symptoms associated with the common cold.

Dietary supplement: For use as a dietary supplement.

ZINC GLUCONATE (CARNIVITA FORTE) DESCRIPTION
Zinc Gluconate (Carnivita forte) Capsule: Each capsule contains zinc sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, vitamin B12 (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, folic acid 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.

Zinc Gluconate (Carnivita forte) Syrup: Each 5 mL contains Zinc Gluconate (Carnivita forte) 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.

ZINC GLUCONATE (CARNIVITA FORTE) DOSAGE
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule,

Oral [preservative free]:
Zn-50: 50 mg [dye free, sugar free, yeast free]

Gum,

Oral:
Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [bubble-gum flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (20 ea [DSC]) [cinnamon flavor]

Lozenge, Mouth/Throat:

Zinc Gluconate (Carnivita forte): 13.3 mg (6 ea [DSC])

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [cherry flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [citrus flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [honey-lemon flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [menthol flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea [DSC]) [tropical fruit flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (2 ea, 10 ea, 18 ea, 24 ea) [gluten free; cherry flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea, 24 ea) [gluten free; honey-lemon flavor]

Zinc Gluconate (Carnivita forte): 13.3 mg (18 ea) [gluten free; tropical orange flavor]

Generic: 10 mg (100 ea)

Lozenge, Mouth/Throat [preservative free]:

Zinc Gluconate (Carnivita forte) Sugar Free: 13.3 mg (18 ea) [gluten free, no artificial color(s), sugar free]

Zinc Gluconate (Carnivita forte) Sugar Free: 13.3 mg (18 ea, 24 ea) [gluten free, no artificial color(s), sugar free; cherry flavor]

Tablet,

Oral:
Generic: 15 mg, 30 mg, 50 mg, 100 mg

Tablet,

Oral [preservative free]:
Generic: 50 mg [DSC]

Dosing: Adult
Common cold: Note: For best results, begin therapy 24 to 48 hours prior to symptom onset:

Oral: Dissolve one 13.3 mg lozenge in mouth every 2 to 4 hours as needed. Maximum: 6 lozenges daily.

Dietary supplement:

Oral: One capsule/tablet daily or as directed by health care provider.

Dosing: Geriatric
Refer to adult dosing.

Dosing: Pediatric
Common cold: Note: Consult product-specific labeling for manufacturer-recommended ages. For best results, begin therapy 24 to 48 hours prior to symptom onset: Zinc Gluconate (Carnivita forte) Lozenge: Children ≥12 years and Adolescents:

Oral topical: Dissolve one lozenge in mouth every 2 to 4 hours as needed. Age-dependent maximum daily dose: 12 to 17 years: 4 lozenges/day; ≥18 years: 6 lozenges/day.

Zinc deficiency, treatment: Limited data available: Note: Dosage expressed in terms of elemental zinc (Kliegman 2016)

Acquired: Infants, Children, and Adolescents:

Oral: 0.5 to 1 mg/kg/day
Acrodermatitis enteropathica:Infants, Children, and Adolescents:

Oral: 3 mg/kg/day

ZINC GLUCONATE (CARNIVITA FORTE) INTERACTIONS

Do not use in combination with tetracyclines because of the risk of chelation in the gut with reduced intestinal absorption.

- For the same reasons, we avoid the association with the following medications:

. dressings gastric alkaline

. medication with calcium or iron.

- Due to interference on the intestinal absorption, foods high in phytic acid will be excluded from the next meal making Zinc Gluconate (Carnivita forte) (eg wholemeal bread, soy beans, corn kernels).

ZINC GLUCONATE (CARNIVITA FORTE) SIDE EFFECTS

Adverse Reactions
Frequency not defined; may vary with different salts. Adverse reactions reported with excess dietary zinc (IOM 2001).

Central nervous system: Headache

Endocrine & metabolic: Copper deficiency, decreased HDL cholesterol, decreased LDL cholesterol

Gastrointestinal: Abdominal cramps, decreased appetite, diarrhea, epigastric pain, gastrointestinal distress, nausea, vomiting

Hematologic & oncologic: Immunodeficiency

Zinc Gluconate (Carnivita forte) contraindications

In clinical studies and bibliography, not known to date.

- Excipients with known effects:

. Wheat starch: hypersensitivity or intolerance to gluten (celiac disease).

. Lactose-cons in individuals suffering from galactosemia or malabsorption of glucose / galactose or lactase deficiency.

- Do not use in combination with tetracyclines because of the risk of chelation in the gut with reduced intestinal absorption.

- For the same reasons, we avoid the association with the following medications:

. dressings gastric alkaline

. medication with calcium or iron.

- Due to interference on the intestinal absorption, foods high in phytic acid will be excluded from the next meal making Zinc Gluconate (Carnivita forte) (eg wholemeal bread, soy beans, corn kernels).

REFERENCES
PubChem. "ZINC GLUCONATE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
PubChem. "Zinc". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
DrugBank. "Zinc gluconate". http://www.drugbank.ca/drugs/DB11248 (accessed September 17, 2018).

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