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Descriptions
Sofosbuvir is used in combination with ribavirin with or without injectable peginterferon alfa to treat chronic hepatitis C infection in adults and children 3 years of age and older (including patients with or without cirrhosis).
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
Packet
Tablet
Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of sofosbuvir in children younger than 3 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sofosbuvir in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Rifampin
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Adagrasib
Amiodarone
Asciminib
Atazanavir
Berotralstat
Capmatinib
Carbamazepine
Cyclosporine
Dabigatran Etexilate
Danicopan
Eltrombopag
Fosphenytoin
Itraconazole
Mavorixafor
Meperidine
Methadone
Momelotinib
Phenytoin
Repotrectinib
Rifapentine
Rosuvastatin
St John's Wort
Tipranavir
Vadadustat
Warfarin
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Heart disease or
Liver disease, advanced—May increase risk for bradycardia (slow heartbeat).
Hepatitis B infection, history of—Use with caution. May cause this disease to become active again.
Kidney disease, severe or
Liver cirrhosis, decompensated or
Liver transplant, history of—It is not known if this medicine will work in patients with these conditions.
Proper Use
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine should come with a patient information leaflet. Read and follow the information carefully. Ask your doctor if you have any questions.
You may take this medicine with or without food.
If you are using the oral pellets:
Do not open the packet until ready to use. Do not use a packet if the seal is broken or damaged.
Hold the packet with the cut line on top and shake it gently to settle the pellets.
Tear or cut the packet along the cut line.
Swallow the oral pellets with water. Do not crush or chew them.
If the oral pellets are taken with food, sprinkle the pellets on 1 or more spoonfuls of non-acidic soft food (eg, pudding, chocolate syrup, mashed potato, and ice cream) at or below room temperature.
Swallow the mixture right away (within 30 minutes). Do not save any of the mixture to use later.
To help clear up your infection completely, sofosbuvir must be taken together with peginterferon alfa and ribavirin for the full time of treatment, even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, sofosbuvir must be used on a regular schedule.
Dosing
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage forms (pellets or tablets):
For hepatitis C virus infection, in combination with peginterferon alfa and ribavirin:
Adults—400 milligrams (mg) once a day, taken for 12 or 24 weeks.
Children 3 years of age and older weighing at least 35 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. The dose is usually one 400 mg tablet once a day or two 200 mg tablets once a day, or two 200 mg packets of pellets once a day, taken for 12 or 24 weeks.
Children 3 years of age and older weighing 17 to less than 35 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually one 200 mg tablet once a day or one 200 mg packet of pellets once a day, taken for 12 or 24 weeks.
Children 3 years of age and older weighing less than 17 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually one 150 mg packet of pellets once a day, taken for 12 or 24 weeks.
Children younger than 3 years of age—Use and dose must be determined by your doctor.
*Missed Dose
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep the medicine in the original container.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine together with ribavirin while you are pregnant can harm your unborn baby. These medicines may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using these medicines, tell your doctor right away.
Using this medicine with amiodarone may cause bradycardia. Check with your doctor right away if you have chest pain or discomfort, lightheadedness, dizziness, or fainting, shortness of breath, slow or uneven heartbeat, or unusual tiredness.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
*More common:
Chills
fever
lower back or side pain
pale skin
ulcers, sores, or white spots in the mouth
unusual tiredness or weakness
*Rare:
Changes in behavior
discouragement
feeling sad or empty
loss of interest or pleasure
thoughts of killing oneself
trouble concentrating
Incidence not known
Chest pain or discomfort
lightheadedness, dizziness, or fainting
shortness of breath
slow or irregular heartbeat
unusual tiredness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
*More common:
Decreased appetite
diarrhea
difficulty with moving
headache
irritability
lack or loss of strength
muscle aching or cramping
muscle pains or stiffness
nausea
rash or itching skin
trouble sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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