Cervitam ( Piracetam 400 mg + Vincamine 20 mg ) 20 capsules

Composition:

Each capsule contains :

Piracetam 400 mg
Vincamine 20 mg

Properties:

Piracetam: It is neotropic, known as intelligence booster. It facilitates the oxygen supply to the brain and enhances communication between the left and right parts of the brain. It also enhances the memory.

Vincamine: It has been proven that it is very effective in increasing concentration and attention. It is vasodilator, it increases blood flow and circulation specially in cases of cerebral insufficiency of various types. More and above Vincamine has very low toxicity, as it is an extract of plant origin.

Indications:

Symptomatic improvement of vertigoes.
 
Improvement of certain symptoms of pathological intellectual deficiency of geriatrics (troubles of concentration, memory ...... etc.).
 
Treatment of constituted cerebral infarction.
 
Complementary treatment to remedy symptoms of pathologic cognitive deficiency and chronic neurosensorial for geriatrics (excluding Alzheimer and other mental disturbances).

Contraindications:

*Severe renal insufficiency (if there is no dialysis, it is not advisable to use high dosage for short intervals).

Absolute:

Hypersensitivity to one of the components.
 
Cerebral nee-formation with intercranial hypertension
 
Usage with certain medications causing extremities twist e.g. Bepridil, Bretylium, Disopyramide, Erythromycin (l.V), Quinidin and Sultopride.

Relative:

Hypokalemia: hypokalemic diuretic, stimulant laxative, Amphotericine (I.V.)
 
Vincamine may provoke extremities twist, it is advisable to observe conditions predisposing extremities twist.
 
Before starting treatment with Vincamine, it is advisable to correct hypokalemia caused by use of other medications, and bradycardia of all origins
 
Auriculoventricular conduction troubles
 
Cardiac arrythmia, Vincamine should be used with caution and under strict surveillance.

Warnings & Precautions:

In cases of renal insufficiency, dose should be modified. As Cervitam is totally eliminated in urine, it is preferable to reduce doses or to increase time between doses, when clearance is less than 60 ml/min. In absence of control on plasmatic rates of Piracetam, it is preferable to reduce the doses or to increase time between doses, according to values of creatinin clearance.

Interactions:

Prohibited concomitance, with Bepridil, Bretylium, Erythromycin (l.V.), Quinidines. Inadvisable concomitance with hypokalemic diuretics, amphotericine (l.V), corticoides, stimulant laxatives. Medications causing extremities twist e.g. pentamidine, sparfloxacine, terfenadine.

Side Effects:

Notable cases of nervous agitation, instability, insomnia are accentuated with usage in elderly (5 % incidence). Gastro- intestinal troubles e.g. nausea, vomiting, diarrhea, gastralgia ( 2 % of cases ). Possibility of widening of QT space and risk of extremities twist.

Dosage & Mode of Administration:

1-2 capsules three times daily (according to severity of the case).

N.B. Capsules should be swallowed as whole (without opening or chewing it), with half glass of water.

Packing:
Box of 20 capsules in two strips (10 capsules each)

Store:
Store below 25°C, Protect from light, Keep out of reach of children.

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