HIDROFEROL 0.266 MG ( CALCIFEDIOL MONOHYDRATE ) 5 SOFT CAPSULES

HIDROFEROL 0.266 mg – 5 Soft Capsules

Calcifediol Monohydrate (25-Hydroxyvitamin D₃)

Hidroferol 0.266 mg contains 0.266 mg (266 micrograms) of calcifediol monohydrate per soft capsule. Calcifediol, also known as 25-hydroxyvitamin D₃ [25(OH)D₃], is the major circulating form of vitamin D and an intermediate metabolite that is converted mainly in the kidneys to the biologically active hormone calcitriol.

Medical Description

Hidroferol 0.266 mg is a high-dose vitamin D preparation used to correct or prevent vitamin D deficiency in adults when higher-dose or intermittent vitamin D administration is appropriate. The product's active ingredient, calcifediol monohydrate, is one metabolic step closer to active vitamin D than cholecalciferol (vitamin D₃), because it does not require the initial hepatic 25-hydroxylation step.

Vitamin D is essential for calcium and phosphorus homeostasis, intestinal calcium absorption, bone mineralization, and normal skeletal health. Adequate vitamin D helps prevent disorders associated with severe deficiency, including rickets in children and osteomalacia in adults.

Key Benefits & Clinical Uses

Hidroferol may be used under medical supervision to:

• Correct vitamin D deficiency and restore adequate circulating 25-hydroxyvitamin D levels.
• Support calcium and phosphorus absorption and metabolism.
• Support normal bone mineralization and skeletal health.
• Help prevent complications associated with significant vitamin D deficiency.
• Provide vitamin D supplementation in adults with specific risk factors for deficiency.
• Serve as an adjunct to appropriate treatment of osteoporosis when vitamin D deficiency or increased risk of deficiency is present.

Calcifediol can raise circulating 25(OH)D concentrations relatively rapidly and has a more predictable dose-response relationship than conventional vitamin D₃ in certain clinical settings. It may be particularly useful in selected patients with malabsorption, obesity, or hepatic problems, although the choice of vitamin D preparation should be individualized by a healthcare professional.

Active Ingredient

Each soft capsule contains:

• Calcifediol monohydrate – 0.266 mg (266 micrograms)
• Equivalent to calcifediol (25-hydroxyvitamin D₃)

Pack size: 5 soft capsules.

How It Works

After administration, calcifediol directly increases circulating 25(OH)D, the principal laboratory marker used to assess vitamin D status. It can subsequently be converted, predominantly in the kidneys, to calcitriol [1,25-dihydroxyvitamin D₃], the active hormonal form of vitamin D. Calcitriol promotes intestinal absorption of calcium and phosphorus and participates in regulation of parathyroid hormone and bone metabolism.

Dosage & Administration

The dose and dosing interval should be individualized according to the patient's serum 25(OH)D level, clinical condition, age, comorbidities, and response to treatment.

Importantly, Hidroferol 0.266 mg is not intended to be taken as a conventional daily vitamin D supplement. Intermittent regimens such as monthly, every two weeks, or other schedules may be prescribed depending on the indication and severity of deficiency. The official product information specifically emphasizes that dosing should be determined according to clinical circumstances and vitamin D levels.

Do not take an additional dose or increase the frequency without medical advice, because excessive vitamin D exposure can lead to elevated blood calcium levels.

Important Warnings & Precautions

• Use only according to the prescribed or recommended dosing schedule.
• Avoid combining with other high-dose vitamin D products unless advised by a healthcare professional.
• Excessive vitamin D intake can cause hypercalcemia and hypercalciuria, potentially leading to nausea, vomiting, weakness, excessive thirst, frequent urination, kidney stones, or kidney complications.
• Particular caution is required in people with kidney disease, hypercalcemia, hypercalciuria, calcium-containing kidney stones, or disorders affecting vitamin D metabolism.
• Patients receiving prolonged treatment may require monitoring of serum calcium, phosphate, creatinine and 25(OH)D, depending on the clinical situation.
• Keep out of the reach of children.

Important Patient Information

Hidroferol 0.266 mg is a high-dose vitamin D medicinal preparation rather than an ordinary daily multivitamin. Its intermittent dosing should be followed carefully. The appropriate frequency depends on the individual's vitamin D status and medical needs.

Patient Disclaimer

This product is a medicinal vitamin D preparation and is not intended to diagnose, treat, cure, or prevent any disease without appropriate medical supervision. Do not use it as a substitute for a balanced diet or healthy lifestyle. Consult your physician or pharmacist before use, especially if you have kidney disease, calcium disorders, kidney stones, malabsorption, osteoporosis, or are taking other vitamin D or calcium-containing products. Do not exceed the recommended dose.

References

1. NIH Office of Dietary Supplements (ODS) – Vitamin D: Health Professional Fact Sheet.
2. Spanish Agency of Medicines and Medical Devices (AEMPS/CIMA) – Hidroferol 0.266 mg Soft Capsules, official product information.
3. MedlinePlus – Calcifediol Drug Information, U.S. National Library of Medicine/NIH.
4. Clinical review: Calcifediol – pharmacological characteristics and clinical use in correcting vitamin D deficiency.
5. Clinical management of vitamin D deficiency in adults – expert position statement.
6. ClinicalTrials.gov – Calcifediol 0.266 mg (Hidroferol) clinical study information.

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