DURY – DIETARY SUPPLEMENT SACHETS

Dosage Form: Oral powder sachets.

Sachet Weight: 2 g per sachet.

Pack Size: 10 sachets.

Manufacturer: Nutrixia.

For: Infnil.

Country of Origin: Egypt.

Product Overview

Dury is a herbal dietary supplement formulated with a combination of plant-derived ingredients traditionally used to support urinary tract function and promote urine production.

Its formula combines parsley seeds, celery seeds, basil leaves, Cortaderia selloana, and Ammi visnaga (Khella), which have traditional uses in herbal preparations associated with urinary health and diuretic activity.

The product is intended to support normal urinary flow and help promote fluid elimination through the kidneys.

Important: Dury is a dietary supplement, not a replacement for prescribed diuretics or medical treatment of kidney stones, urinary tract infections, or other urinary disorders. Scientific evidence supporting the effectiveness of this specific combination is limited.

Composition and Ingredients

Each 2 g sachet contains:

Other Ingredients:

• Dextrose.
• Maltodextrin.

The remaining 250 mg of the sachet weight consists of other ingredients.

Potential Benefits and Traditional Uses

Based on the traditional uses of its herbal ingredients, Dury may offer the following supportive properties:

1. Urinary Flow Support: Traditionally used herbal ingredients may support normal urine production and urinary flow.
2. Mild Diuretic Support: Parsley and celery seeds have traditional use in herbal preparations intended to promote urination.
3. Urinary Tract Support: Provides a combination of botanical ingredients traditionally associated with urinary wellness.
4. Fluid Elimination: May support the body's natural process of eliminating excess fluid through urine.
5. Herbal Urinary Wellness: Combines several plant-derived ingredients traditionally used in preparations for urinary health.

Scientific note: These are traditional or proposed uses, not established clinical benefits of Dury. There is insufficient high-quality clinical evidence to confirm that this product treats urinary disorders or dissolves kidney stones.

Mechanism of Action

The herbal ingredients have traditionally been associated with several potential physiological activities:

• Parsley Seeds: Traditionally used for their potential diuretic properties, which may support urine production.
• Celery Seeds: Contain naturally occurring phytochemicals that have been investigated for their potential effects on fluid balance and urinary function.
• Basil Leaves: Contain polyphenols and other antioxidant compounds that contribute to their botanical properties.
• Cortaderia selloana: A botanical ingredient included in the formulation for traditional herbal urinary support; clinical evidence for its effects is limited.
• Ammi visnaga (Khella): Contains compounds such as khellin and visnagin, which have been studied for their smooth-muscle-relaxant and antispasmodic properties.

The combined formulation is intended to provide supportive urinary and diuretic activity; however, the clinical effects of the complete combination have not been established.

Recommended Usage and Administration

According to the manufacturer's package instructions:

• Dissolve one sachet (2 g) in half a cup of water.
• Stir until adequately dispersed.
• Sweeten as desired.

Important: The package does not specify the frequency of administration or treatment duration. Follow the manufacturer's complete instructions or consult a healthcare professional for the appropriate daily intake.

Possible Side Effects

Although Dury contains plant-derived ingredients, herbal supplements may still cause adverse reactions.

Possible side effects include:

• Gastrointestinal discomfort.
• Nausea or stomach upset.
• Allergic reactions in sensitive individuals.
• Increased urination.
• Possible dehydration or electrolyte disturbances if excessive diuretic activity occurs.
• Photosensitivity reactions associated with Khella (Ammi visnaga).

Prolonged or excessive oral use of Khella has also been associated with elevated liver enzymes and potential liver toxicity.

Contraindications and Precautions

Dury should be avoided or used only following medical assessment in the following situations:

• Pregnancy: Avoid use, particularly because Ammi visnaga has potential uterine-stimulant activity.
• Breastfeeding: Safety has not been adequately established.
• Kidney Disease: Patients with impaired kidney function should consult their physician before use.
• Liver Disease: Khella-containing preparations require particular caution because of potential liver-related adverse effects.
• Dehydration: Avoid unsupervised use in patients with dehydration or electrolyte imbalances.
• Herbal Allergies: Avoid use in individuals with known hypersensitivity to any of the ingredients.
• Cardiovascular Conditions: Patients with heart disease or blood pressure abnormalities should seek medical advice before use.

Additional precaution: Khella may cause photosensitivity. Avoid excessive sunlight and ultraviolet exposure during use.

Drug Interactions

Potential interactions should be considered, particularly because of the presence of Ammi visnaga and other botanicals.

1. Anticoagulants: Khella-containing preparations may interact with blood-thinning medications, including warfarin.
2. Antihypertensive Medications: Potential additive blood-pressure-lowering effects may occur.
3. Calcium Channel Blockers: Khella may interact with medications belonging to this class.
4. Diuretics: Concurrent use may increase the risk of excessive fluid loss and electrolyte disturbances.
5. Photosensitizing Medications: Combining Khella with certain medications that increase sensitivity to sunlight may increase photosensitivity risk.

Patients taking regular medications should consult their physician or pharmacist before using Dury.

Storage Conditions

• Store in a cool, dry place.
• Protect from direct sunlight and moisture.
• Keep sachets sealed until use.
• Keep out of reach of children.
• Do not use after the expiry date printed on the package.

Product Presentation

1. Egyptian Drug Authority (EDA): Egyptian Herbal Monograph on Ammi visnaga, including safety, contraindications, and precautions. EDA – Ammi visnaga Herbal Monograph.
2. Department of Health – Abu Dhabi: Educational information on Ammi visnaga, traditional uses, and safety precautions. Ammi visnaga – Medicinal Plant Information.
3. U.S. National Library of Medicine (PubMed Central): Review of Ammi visnaga, its traditional uses, pharmacological properties, and safety profile. Ammi visnaga – Pharmacological and Clinical Review.
4. Mayo Clinic: Evidence and safety considerations concerning natural diuretics and herbal supplements. Mayo Clinic – Are There Natural Diuretics?.
5. Scientific Review – SAGE Journals: Potential drug-herb interactions involving medicinal plants used in urinary stone disease. Medicinal Plants and Potential Drug Interactions.

Patient Disclaimer

This information is provided for educational purposes only and should not replace professional medical advice, diagnosis, or treatment.

Dury is a dietary supplement and should be used according to the manufacturer's instructions. Consult a qualified healthcare professional before use, especially if you have kidney or liver disease, cardiovascular conditions, are pregnant or breastfeeding, or take other medications.

Increased urination does not necessarily indicate improved kidney function or the elimination of kidney stones. Persistent urinary symptoms, blood in the urine, fever, or severe flank pain require medical evaluation.

This product is not intended to diagnose, treat, cure, or prevent any disease.