EVA SKIN CLINIC ANTI-AGEING NIACINAMIDE 10% & ZINC 1% FACIAL SERUM 30 ML

Eva Skin Clinic Niacinamide Facial Serum with Nicinamide for clear and hydrated skin ( 10% Nicinamide & 1% Zinc )

EVA Skin Clinic Anti-Aging Niacinamide 10% & Zinc 1% Facial Serum is a topical dermatologic serum formulated to target multiple common skin concerns including excess sebum production, enlarged pores, uneven skin tone, barrier dysfunction, and early signs of aging. It combines high-strength niacinamide (Vitamin B3) with Zinc PCA, a sebum-regulating zinc derivative, to modulate skin physiology through well-studied mechanisms.

Pharmacologic Actions

Niacinamide (10%)

• A water-soluble vitamin B3 derivative with multi-functional dermatologic properties.
• Enhances epidermal barrier function by up-regulating synthesis of ceramides and other lipids, leading to improved hydration and reduced transepidermal water loss (TEWL).
• Exerts anti-inflammatory effects, reducing erythema and irritation in inflammatory skin conditions.
• Reduces the appearance of fine lines and wrinkles by supporting collagen and keratin production.
• Regulates melanosome transfer, helping to reduce hyperpigmentation and even out skin tone.

Zinc PCA (1%)

• A zinc salt of L-pyrrolidone carboxylic acid with sebum-modulating and antimicrobial activity.
• Helps to normalize excess oil production and may inhibit proliferation of acne-associated bacteria, supporting clearer skin.
• Has anti-inflammatory properties that can contribute to reduced irritation and redness.

Clinical Indications

This serum is primarily indicated for:

• Sebum imbalance and oily or combination skin — regulation of oil production reduces shine and pore size appearance.
• Enlarged pores — by reducing sebum output and improving epidermal structure.
• Early signs of photoaging — improved barrier and increased collagen synthesis can reduce fine lines and texture irregularities.
• Compromised skin barrier / dehydration — boosted barrier function supports retention of moisture.

Mechanism of Action

1. Barrier Restoration: Niacinamide increases lipid synthesis, improving skin hydration and resilience.
2. Sebum Control: Zinc PCA modulates oil production at the sebaceous glands, decreasing pore clogging and shine.
3. Anti-Inflammatory: Both ingredients reduce pro-inflammatory signaling in epidermal keratinocytes and sebocytes.
4. Pigment Regulation: Niacinamide inhibits melanosome transfer to keratinocytes, leading to reduced appearance of hyperpigmented lesions.

Use and Treatment Protocol

• Apply 3–4 drops to cleansed face and neck once or twice daily (morning/evening).
• Allow full absorption before applying moisturizer or sunscreen.
• For optimal results in aging or photoexposed skin, combine with broad-spectrum sunscreen during the day.

Expected Benefits

With consistent use (typically several weeks):

• Improved skin texture and tone
• Reduced visibility of pores and shine
• Enhanced hydration and barrier function
• Reduced fine lines and early aging signs
• More uniform pigmentation and fewer blemishes

Safety and Precautions

• For external use only. Avoid eye contact — if contact occurs, rinse thoroughly.
• Some individuals may experience initial mild irritation or tingling, especially those with sensitive skin.
• Discontinue if persistent irritation occurs and consult a dermatologist.
• Recommended to use sunscreen daily due to increased cellular turnover and repair activity.

Dermatologic Profile

• Often well-tolerated by most skin types including oily and combination skin.
• Niacinamide is generally considered non-sensitizing at concentrations up to 10%; however, individuals with reactive skin should patch-test before widespread use.

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