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Mavyret Tablets ( Glecaprevir 100 mg / Pibrentasvir 40 mg )
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Chronic Hepatitis C
Indicated for patients with genotypes 1-6 without cirrhosis or with compensated cirrhosis
Treatment-experienced patients with genotype 1 previously treated with a regimen containing NS5A inhibitor or an NS3/4A protease inhibitor, but not both
3 tablets (ie, 300 mg/120 mg total dose) PO qDay
Recommended duration
-
Treatment-naïve patients
- Genotypes 1-6, no cirrhosis or compensated cirrhosis (Child-Pugh A): 8 weeks
-
Treatment-experienced patients
- No cirrhosis
- Genotype 1 and NS5A inhibitor without prior treatment with an NS3/4A protease inhibitor (PI): 16 weeks
- Genotype 1 and NS3/4A PI without prior treatment with an NS5A inhibitor: 12 weeks
- Genotypes 1, 2, 4, 5, or 6 (prior treatment with simeprevir and sofosbuvir, or simeprevir, boceprevir, or telaprevir with pegylated interferon and ribavirin): 8 weeks
- Genotype 3 (prior treatment with simeprevir and sofosbuvir, or simeprevir, boceprevir, or telaprevir with pegylated interferon and ribavirin): 16 weeks
- Compensated cirrhosis (Child-Pugh A)
- Genotype 1 and NS5A inhibitor without prior treatment with an NS3/4A protease inhibitor (PI): 16 weeks
- Genotype 1 and NS3/4A PI without prior treatment with an NS5A inhibitor: 12 weeks
- Genotypes 1, 2, 4, 5, or 6 (prior treatment with simeprevir and sofosbuvir, or simeprevir, boceprevir, or telaprevir with pegylated interferon and ribavirin): 12 weeks
- Genotype 3 (prior treatment with simeprevir and sofosbuvir, or simeprevir, boceprevir, or telaprevir with pegylated interferon and ribavirin): 16 weeks
- No cirrhosis
-
Liver or kidney transplant recipients
- Treatment duration is 12 weeks
-
16-week treatment duration recommended
- Genotype 1-infected patients who are NS5A inhibitor-experienced without prior treatment with an NS3/4A protease inhibitor
- Genotype 3-infected patients who are treatment experience with regimens containing (peg)interferon, ribavirin, and/or sofosbuvir, but no prior treatment experience with an HCV NS3/4A PI or NS5A inhibitor
Dosage Modifications
Renal impairment
- Mild, moderate, or severe, including patients on dialysis: No dosage adjustment required
Hepatic impairment
- Mild (Child-Pugh A): No dosage adjustment required
- Moderate-to-severe (Child-Pugh B or C): Contraindicated
- Patients with any history of prior hepatic decompensation: Contraindicated
Dosing Considerations
Test for evidence of current or prior hepatitis B virus (HBV) infection by measuring hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) before initiating HCV treatment
Interactions
Contraindicated (2)
- elagolix
- rifampin
Serious - Use Alternative (15)
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