Product Code: 70861
Availability: In Stock
Price: 3,970EGP
Ex Tax: 3,970EGP



You can return the product within 14 days of purchase.


You can return the product within 14 days of purchase.

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MPI VIROPAC PLUS ( sofsobuvir 400 mg + ledipasvir 90 mg ) 28 tablets 

 is a two-drug combination for the treatment of hepatitis C. It is administered as a single daily pill containing 90 mg of the viral NS5A inhibitor ledipasvir and 400 mg of sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase.

Ledipasvir/sofosbuvir was developed by the pharmaceutical company Gilead Sciences and first marketed in October 2014. Taken daily for 8–12 weeks, it provides cure rates of 94% to 99% in people infected with genotype 1 (the most common form of hepatitis C in the U.S. and some European countries), irrespective of the presence or absence of liver cirrhosis or prior unsuccessful treatment. It has also been evaluated for the treatment of infection with other hepatitis C genotypes, and has shown promising results in genotypes 3 and 4

Indications and Usage for MPI Viropack Plus

​MPI Viropack Plus is indicated with or without ribavirin for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1, 4, 5, or 6 infection.

MPI Viropack Plus Dosage and Administration

Recommended Dosage

The recommended dosage of MPI Viropack Plus is one tablet taken orally once daily with or without food.

Mechanism of action of Viropack Plus (Ledipasvir 90 mg + Sofosbuvir 400 mg):

- Ledipasvir is a HCV inhibitor targeting the HCV NS5A protein, which is essential for both RNA replication and the assembly of HCV virions. Biochemical confirmation of NS5A inhibition by ledipasvir is not currently possible as NS5A has no enzymatic function. In vitro resistance selection and cross-resistance studies indicate ledipasvir targets NS5A as its mode of action.
- Sofosbuvir is a pan-genotypic inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analogue triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. GS-461203 (the active metabolite of sofosbuvir) is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase.

** Store at temperature not exceeding 30 degrees C, in a dry place.
Keep out of reach of children.

Drug interactions

Always consult your doctor and pharmacist about all the other prescription and non-prescription drugs you are taking, including methadone or other opiate substitution therapies, herbs, supplements and street drugs.

Drug interactions occur when one medication affects how another is absorbed, used or flushed out of the body. Some drugs can interact with Harvoni, increasing or decreasing the level of one or both drugs in the body. Increased levels can lead to new or more severe side effects. Decreased levels may mean that the drug won’t be as effective.

 This is not a complete list of possible drug interactions with Harvoni.

It is not recommended to take Harvoni with the following medications:

  • medication to treat irregular heartbeat, such as amiodarone
  • cholesterol-lowering medication, such as rosuvastatin (Crestor)
  • anti-seizure medication, such as carbamazepine (Tegretol), phenobarbital, oxcarbazepine (Trileptal) and phenytoin (Dilantin)
  • some hepatitis C medications, such as simeprevir (Galexos)
  • tuberculosis medication, such as rifampin
  • any medicinal herbs, especially an herb used to treat depression – St. John’s wort (Hypericum perforatum), or hyperforin or hypericin, active ingredients in St. John’s wort
  • HIV medication, such as:
    • Stribild (elvitegravir + cobicistat + emtricitabine + tenofovir);
    • tipranavir (Aptivus) + ritonavir (Norvir)

When it  is taken with the following medications it could potentially cause significant drug interactions:

  • antacids or buffered medications
  • HIV medication, such as:
    • Atripla (efavirenz + emtricitabine + tenofovir);
    • tenofovir (Viread and in Truvada) used together with atazanavir (Reyataz), darunavir (Prezista, Prezcobix) or Kaletra (lopinavir + ritonavir);
  • medication to treat indigestion, heartburn or ulcers, such as nizatidine (Axid), famotidine (Pepcid AC, Peptic Guard), ranitidine (Zantac), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Losec) and pantoprazole (Pantoloc)

Talk to your nurse, doctor and pharmacist if you are taking any of these medicines. One way to manage drug interactions is to make sure that your doctor and pharmacist know about everything you are taking, including prescription drugs, over-the-counter drugs, street drugs, herbal medications, supplements or anything else. If you have more than one doctor or pharmacist, it is possible for drug interactions to get missed. If more than one doctor is writing prescriptions for you, let each one know about everything you are taking. If possible, use the same pharmacy for all your prescriptions.

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