MPIVIROPACK / MPI VIROPACK 400 mg ( sofosbuvir ) 28 tablets 

Brand Name:  MPIVIROPACK Tablet
Active Ingredient: Sofosbuvir 

When is MPIVIROPACK prescribed for?

MPIviropack is indicated in combination with other medicinal products for the treatment of chronic hepatitis C (CHC) in adults.

How should you take MPIVIROPACK?

• The recommended dose is one 400 mg tablet, taken orally, once daily with food.
• MPIviropack should be used in combination with other medicinal products. Monotherapy of MPIviropack is not recommended.

When you should not take MPIVIROPACK?

Hypersensitivity to the active substance or to any of the excipients.

Special warning and precautions on using MPIVIROPACK:

 • MPIviropack is always taken with other medicines. Talk to your doctor or pharmacist before taking this medicine if you:
- Have liver problems other than hepatitis C, e.g. if you are awaiting a liver transplantation.
- Have hepatitis B, since your doctor may want to monitor you more closely.
- Have kidney problems. Talk to your doctor or pharmacist if you have severe kidney problems or if you are on kidney dialysis as the effects of Sofosbuvir on patients with severe kidney problems have not been fully tested.
​• Do not give this medicine to children and adolescents under 18 years of age. The use of MPIviropack in children and adolescents has not yet been studied.

Possible Drug interaction with MPIVIROPACK:

• Medicinal products that are potent P-gp inducers in the intestine (e.g. rifampicin, St. John's wort, carbamazepine and phenytoin) may decrease sofosbuvir plasma concentration leading to reduced therapeutic effect of MPIviropack and thus should not be used with MPIviropack.
• Co-administration of MPIviropack with medicinal products that inhibit P-gp and/or BCRP may increase sofosbuvir plasma concentration without increasing GS-331007 plasma concentration, thus MPIviropack may be co-administered with P-gp and/or BCRP inhibitors.
• Sofosbuvir and GS-331007 are not inhibitors of P-gp and BCRP and thus are not expected to increase exposures of medicinal products that are substrates of these transporters.

Special information if you are pregnant or breastfeeding

• There are no or limited amount of data (less than 300 pregnancy outcomes) from the use of sofosbuvir in pregnant women.
As a precautionary measure, it is preferable to avoid the use of MPIviropack during pregnancy.
• It is unknown whether sofosbuvir and its metabolites are excreted in human milk.
Therefore, MPIviropack should not be used during breast-feeding.

Side effects

During treatment with sofosbuvir in combination with ribavirin or with peginterferon alfa and ribavirin, the most frequently reported adverse drug reactions were consistent with the expected safety profile of ribavirin and peg interferon Alfa treatment, without increasing the frequency or severity of the expected adverse drug reactions.

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